Dietary l-glutamine supplementation modulates microbial community and activates innate immunity in the mouse intestine

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Ren, Wenkai;Duan, Jielin;Yin, Jie;Liu, Gang;Cao, Zhong;...

通讯作者：

Xiong, Xia

作者机构：

[Liu, Gang; Yin, Jie; Ren, Wenkai; Duan, Jielin; Chen, Shuai; Xiong, Xia; Li, Tiejun; Yin, Yulong] Chinese Acad Sci, Sci Observing & Expt Stn Anim Nutr & Feed Sci Sou, Hunan Prov Engn Res Ctr Hlth Livestock,Minist Agr, Key Lab Agroecol Proc Subtrop Reg,Inst Subtrop Ag, Changsha 410125, Hunan, Peoples R China.

[Liu, Gang; Cao, Zhong] Changsha Univ Sci & Technol, Sch Chem & Biol Engn, Hunan Prov Key Lab Mat Protect Elect Power & Tran, Changsha 410004, Hunan, Peoples R China.

[Hou, Yongqing; Wu, Guoyao; Yin, Yulong] Wuhan Polytech Univ, Hubei Collaborat Innovat Ctr Anim Nutr & Feed Saf, Hubei Key Lab Anim Nutr & Feed Sci, Wuhan 430023, Peoples R China.

[Wu, Guoyao] Texas A&M Univ, Dept Anim Sci, College Stn, TX 77843 USA.

通讯机构：

[Xiong, Xia] C

Chinese Acad Sci, Sci Observing & Expt Stn Anim Nutr & Feed Sci Sou, Hunan Prov Engn Res Ctr Hlth Livestock,Minist Agr, Key Lab Agroecol Proc Subtrop Reg,Inst Subtrop Ag, Changsha 410125, Hunan, Peoples R China.

语种：

英文

关键词：

Glutamine;Paneth cell;Firmicutes;NF-kappa B;Innate immunity

期刊：

Amino Acids

ISSN：

0939-4451

年：

2014

卷：

期：

页码：

2403-2413

DOI：

10.1007/s00726-014-1793-0

基金类别：

National Basic Research Program of ChinaNational Basic Research Program of China [2013CB127301, 2012CB124704, 2012CB126305]; NSFCNational Natural Science Foundation of China (NSFC) [31330075, 31101729, 31301989, 31101730, 31201813, 31301988]; Hunan Provincial Natural Science Foundation of ChinaNatural Science Foundation of Hunan Province [13JJ2034]; Hunan Provincial Key Laboratory of Materials Protection for Electric Power and Transportation [2013CL06]; Changsha University of Science & Technology, P. R. China; Hubei Provincial Research and Development Program [2010BB023]; Natural Science Foundation of Hubei ProvinceNatural Science Foundation of Hubei Province [2012FFB04805]; Hubei One Hundred Talent Program; Texas A&M AgriLife Research [H-82000]

机构署名：

本校为其他机构

院系归属：

化学与生物工程学院

摘要：

This study was conducted to determine effects of dietary supplementation with 1 % l-glutamine for 14 days on the abundance of intestinal bacteria and the activation of intestinal innate immunity in mice. The measured variables included (1) the abundance of Bacteroidetes, Firmicutes, Lactobacillus, Streptococcus and Bifidobacterium in the lumen of the small intestine; (2) the expression of toll-like receptors (TLRs), pro-inflammatory cytokines, and antibacterial substances secreted by Paneth cells and goblet cells in the jejunum, ileum and colon...

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Dietary l-glutamine supplementation modulates microbial community and activates innate immunity in the mouse intestine

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