MiR-29 mediates TGF1-induced extracellular matrix synthesis through activation of PI3K-AKT pathway in human lung fibroblasts

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成果类型：

期刊论文

作者：

Yang, Tao;Liang, Ying;Lin, Qinlu;Liu, Junwen;Luo, Feijun;...

通讯作者：

Zhang, Hongliang

作者机构：

[Luo, Feijun; Yang, Tao; Zhuang, Sheng; Zhou, Hui; Liang, Ying; Lin, Qinlu] Cent South Univ Forestry & Technol, Natl Engn Lab Rice & By Prod Deep Proc, Changsha 410004, Hunan, Peoples R China.

[Yang, Tao; Zhou, Hui] Changsha Univ Sci & Technol, Coll Chem & Bioengn, Changsha 410076, Hunan, Peoples R China.

[Liu, Junwen] Cent S Univ, Sch Basic Med Sci, Dept Histol & Embryol, Changsha 410013, Hunan, Peoples R China.

[Li, Xinhua] Cent S Univ, Xiangya Hosp, Dept Gastroenterol, Changsha 410008, Hunan, Peoples R China.

[Zhang, Hongliang] Cent S Univ, Xiangya Hosp 2, Emergency Dept, Changsha 410011, Hunan, Peoples R China.

通讯机构：

[Zhang, Hongliang] C

Cent S Univ, Xiangya Hosp 2, Emergency Dept, Changsha 410011, Hunan, Peoples R China.

语种：

英文

关键词：

Lung Fibrosis;miR-29;PI3K-AKT;TGFβ1

期刊：

JOURNAL OF CELLULAR BIOCHEMISTRY

ISSN：

0730-2312

年：

2013

卷：

114

期：

页码：

1336-1342

DOI：

10.1002/jcb.24474

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81072038/H1617, 31201348, 30900623]; Changsha Technology Bureau Science and Technology projects [K1201004-31]; China Postdoctoral Science FoundationChina Postdoctoral Science Foundation [201003527]; Hunan Natural Science FoundationNatural Science Foundation of Hunan Province [09JJ3035]; Engineering Research Center of Starch and Plant Protein Processing, Ministry of Education [201107]

机构署名：

本校为其他机构

院系归属：

化学与生物工程学院

摘要：

TGFβ1 is very important in the synthesis and degradation of extracellular matrix, and also in the mediation of human lung fibroblasts proliferation, and miR-29 plays an important role in this process. To explore the interactions of miR-29 family members and TGFβ1, the effects of transforming growth factor TGFβ1 on the expression of miR-29 and whether miR-29 is involved in pro-survival signaling pathways mediated by TGFβ1 were examined in human lung fibroblasts. Treatment of the human embryonic lung fibroblast cell line IMR90 with TGFβ1 cau...

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MiR-29 mediates TGF1-induced extracellular matrix synthesis through activation of PI3K-AKT pathway in human lung fibroblasts

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