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Rationally designed molecular beacons for bioanalytical and biomedical applications

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成果类型:
期刊论文
作者:
Zheng, Jing;Yang, Ronghua*;Shi, Muling;Wu, Cuichen;Fang, Xiaohong;...
通讯作者:
Yang, Ronghua
作者机构:
[Zheng, Jing; Yang, Ronghua; Shi, Muling; Li, Yinhui; Li, Jishan; Fang, Xiaohong; Tan, Weihong] Hunan Univ, Mol Sci & Biomed Lab, State Key Lab Chemo Biosensing & Chemomet, Coll Chem & Chem Engn, Changsha 410082, Hunan, Peoples R China.
[Zheng, Jing; Yang, Ronghua; Shi, Muling; Li, Yinhui; Li, Jishan; Fang, Xiaohong; Tan, Weihong] Hunan Univ, Collaborat Res Ctr Mol Engn Theranost, Changsha 410082, Hunan, Peoples R China.
[Yang, Ronghua] Changsha Univ Sci & Technol, Sch Chem & Biol Engn, Changsha 410004, Hunan, Peoples R China.
[Wu, Cuichen; Tan, Weihong] Univ Florida, UF Genet Inst & McKnight Brain Inst, Dept Chem, Ctr Res Bionano Interface,Shands Canc Ctr, Gainesville, FL 32611 USA.
[Wu, Cuichen; Tan, Weihong] Univ Florida, UF Genet Inst & McKnight Brain Inst, Dept Physiol & Funct Gen, Ctr Res Bionano Interface,Shands Canc Ctr, Gainesville, FL 32611 USA.
通讯机构:
[Yang, Ronghua] H
Hunan Univ, Mol Sci & Biomed Lab, State Key Lab Chemo Biosensing & Chemomet, Coll Chem & Chem Engn, Changsha 410082, Hunan, Peoples R China.
语种:
英文
期刊:
Chemical Society Reviews
ISSN:
0306-0012
年:
2015
卷:
44
期:
10
页码:
3036-3055
基金类别:
National Key Scientific Program of China [2011CB911000]; National Natural Science Foundation of China [21135001, 21405038, 21327009]; Foundation for Innovative Research Groups of NSFC [21221003]; China National Instrumentation Program [2011YQ03012412]; National Institutes of Health [GM079359, CA133086]; Fundamental Research Funds for the Central Universities; American Chemical Society; Division of Analytical Chemistry Fellowship; Society for Analytical Chemists of Pittsburgh
机构署名:
本校为其他机构
院系归属:
化学与生物工程学院
摘要:
Nucleic acids hold promise as biomolecules for future applications in biomedicine and biotechnology. Their well-defined structures and compositions afford unique chemical properties and biological functions. Moreover, the specificity of hydrogen-bonded Watson-Crick interactions allows the construction of nucleic acid sequences with multiple functions. In particular, the development of nucleic acid probes as essential molecular engineering tools will make a significant contribution to advancements in biosensing, bioimaging and therapy. The molec...

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