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Universal Fluorescence Biosensor Platform Based on Graphene Quantum Dots and Pyrene-Functionalized Molecular Beacons for Detection of MicroRNAs

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成果类型:
期刊论文
作者:
Zhang, Huan;Wang, Yunsheng;Zhao, Daiwei;Zeng, Dongdong;Xia, Jiaoyun;...
通讯作者:
Zuo, Xiaolei
作者机构:
[Zhang, Huan; Zeng, Dongdong; San, Lili; Wang, Chenguang; Mi, Xianqiang] Chinese Acad Sci, Shanghai Adv Res Inst, Lab Syst Biol, Shanghai 201210, Peoples R China.
[Zhao, Daiwei; Wang, Yunsheng] Guizhou Med Univ, Affiliated Hosp 2, Thyroid Surg, Kaili 556000, Peoples R China.
[Xia, Jiaoyun] Changsha Univ Sci & Technol, Sch Chem & Biol Engn, Changsha 410114, Hunan, Peoples R China.
[Fan, Chunhai; Xia, Jiaoyun; Zuo, Xiaolei] Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai Synchrotron Radiat Facil, Div Phys Biol, Shanghai 201800, Peoples R China.
[Fan, Chunhai; Xia, Jiaoyun; Zuo, Xiaolei] Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai Synchrotron Radiat Facil, Bioimaging Ctr, Shanghai 201800, Peoples R China.
通讯机构:
[Zuo, Xiaolei] C
Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai Synchrotron Radiat Facil, Div Phys Biol, Shanghai 201800, Peoples R China.
语种:
英文
关键词:
biosensor;pyrene;graphene quantum dots;fluorescence resonance energy transfer;microRNA
期刊:
ACS Applied Materials & Interfaces
ISSN:
1944-8244
年:
2015
卷:
7
期:
30
页码:
16152-16156
基金类别:
Shanghai Municipal Science and Technology CommissionScience & Technology Commission of Shanghai Municipality (STCSM) [13DZ1940200, 15441905000]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [11405013]; Shanghai Yang Fan Plan [15YF1413300]; Deanship of Scientific Research, College of Science Research Center, King Saud University
机构署名:
本校为其他机构
院系归属:
化学与生物工程学院
摘要:
A novel biosensor platform was developed for detection of microRNAs (miRNAs) based on graphene quantum dots (GQDs) and pyrene-functionalized molecular beacon probes (py-MBs). Pyrene was introduced to trigger specifically fluorescence resonance energy transfer (FRET) between GQDs and fluorescent dyes labeled on py-MBs, and the unique fluorescent intensity change produced a novel signal for detection of the target. The platform realized detection of miRNAs in a wide range from 0.1 nM to 200 nM with great discrimination abilities, as well as multi...

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