期刊论文

Yang, RM;Zhou, YB

英文

Biosensors and Bioelectronics

0956-5663

2024

253

116144

10.1016/j.bios.2024.116144

sources This work is supported by the National Natural Science Foundation of China (82200280), and Open Research Fund of Hunan Provincial Key Laboratory of Regional Hereditary Birth Defects Prevention and Control (HPKL2023009), and the China Postdoctoral Science Foundation (2022M713573) and the project of Guangzhou Municipal Health Bureau, China (20231A011006), the Changsha Municipal Natural Science Foundation (kq2208216). CRediT authorship contribution statement Ni Zeng: Methodology, acquisition, Data curation. Xiuhong Guan: Writing – original draft, Software, Resources, Project administration, Methodology, Investigation, Conceptualization. Xiaowen Liu: Validation, Supervision, Software, Resources, Conceptualization. Huiqiu Shi: Writing – review & editing. Nan Li: Writing – original draft, Validation, Supervision. Ruimeng Yang: Writing – review & editing, Writing – original draft, Methodology, Investigation. Yibo Zhou: Methodology,

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Early diagnosis and treatment of renal fibrosis (RF) significantly affect the clinical outcomes of chronic kidney diseases (CKDs). As the typical fibrotic ailment, RF is characterized by remodeling of the extracellular matrix, and the activation of fibroblast activation protein (FAP) plays a crucial role in the mediation of extracellular matrix protein degradation. Therefore, FAP can serve as a biomarker for RF. However, up to now, no effective tools have been reported to diagnose early-stage RF via detecting FAP. In this work, a polymeric nanobeacon integrating an FAP-sensitive amphiphilic po...