Synthesis of poly(l-lactide)/β-cyclodextrin/citrate network modified hydroxyapatite and its biomedical properties

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成果类型：

期刊论文

作者：

Yi, Wen-Jun;Li, Li-Jun;He, Hao;Hao, Zhen;Liu, Bo;...

通讯作者：

Chao, Zi-Sheng;Shen, Yi

作者机构：

[Liu, Bo; Chao, Zi-Sheng; Hao, Zhen; Yi, Wen-Jun] Changsha Univ Sci & Technol, Coll Mat Sci & Engn, Changsha 410082, Hunan, Peoples R China.

[He, Hao; Chao, Zi-Sheng; Li, Li-Jun; Yi, Wen-Jun] Hunan Univ, Coll Chem & Chem Engn, Changsha 410114, Hunan, Peoples R China.

[Shen, Yi] Cent S Univ, Xiangya Hosp 2, Dept Orthopaed, Changsha 410011, Hunan, Peoples R China.

通讯机构：

[Chao, Zi-Sheng; Shen, Yi] C

[Chao, Zi-Sheng] H

Changsha Univ Sci & Technol, Coll Mat Sci & Engn, Changsha 410082, Hunan, Peoples R China.

Hunan Univ, Coll Chem & Chem Engn, Changsha 410114, Hunan, Peoples R China.

Cent S Univ, Xiangya Hosp 2, Dept Orthopaed, Changsha 410011, Hunan, Peoples R China.

语种：

英文

关键词：

beta cyclodextrin;calcium ion;citric acid;hydroxyapatite;hydroxyl group;polylactide;animal cell;Article;biocompatibility;biological activity;biomedical engineering;cell adhesion;cell viability;chelation;controlled study;cross linking;cytotoxicity;mesenchymal stem cell;nonhuman;particle size;priority journal;ring opening metathesis polymerization;surface property;synthesis;tissue engineering

期刊：

NEW JOURNAL OF CHEMISTRY

ISSN：

1144-0546

年：

2018

卷：

期：

页码：

14729-14732

DOI：

10.1039/c8nj01194j

基金类别：

This work was supported by the Natural Science Foundation of Hunan Province (Grant 2017JJ2359), the Program for New Century Excellent Talents in University, the Ministry of Education of P. R. China, and the Program for Fu-Rong Scholar in Hunan Province, P. R. China.

机构署名：

本校为第一且通讯机构

院系归属：

材料科学与工程学院

摘要：

Hydroxyapatite (HA) was modified by the chelation of citric acid and Ca2+ on the surface of HA, followed by cross-linking between the hydroxyl groups of β-cyclodextrin (β-CD) and citrate, and then further in situ ring-opening polymerization of l-lactide over the hydroxyl groups. The modification of HA adjusted its surface properties and reduced the particle size. The synthesized PLA-CD-HA-72 exhibited the good adhesion of mesenchymal stem cells (MSCs) of Wistar rats, higher viability of MSCs and larger osteoinductivity. The results indicated ...

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Synthesis of poly(l-lactide)/β-cyclodextrin/citrate network modified hydroxyapatite and its biomedical properties

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