期刊论文

Xu, F.

中文

药学学报

0513-4870

2009

44

10

1127-1130

10.3321/j.issn:0513-4870.2009.10.012

20833009:国家自然科学基金 20873148:国家自然科学基金 50671098:国家自然科学基金 20775010:国家自然科学基金 U0734005:国家自然科学基金

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用微量量热法测定了37℃时头孢拉定和头孢他定对大肠杆菌DH5α代谢作用的产热曲线.根据产热曲线,分别得到了大肠杆菌DH5α在不同浓度的头孢拉定和头孢他定作用下的生长速率常数k、抑制率I、最大产热功率P_m以及最大产热功率所对应的时间t_m等热动力学参数,从热动力学的角度探讨了头孢拉定和头孢他定对大肠杆菌DH5α代谢作用的影响.实验证明,头孢他定对大肠杆菌的抑制作用比头孢拉定更强.

The effects of cephradinum and ceftazidime on the metabolism of Escherichia coli (E. coli) DH5alpha was determined by microcalorimetry. The microbial activity was recorded as power-time curves through an ampoule method with a TAM Air Isothermal Microcalorimeter at 37 degrees C. The parameters such as the growth rate constant (k), inhibitory ratio (I), the maximum power output (Pm) and the time (tm) corresponding to the maximum power output were calculated. The results show that the ceftazidime has a bett...