A spherical nucleic acid-based two-photon nanoprobe for RNase H activity assay in living cells and tissues

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成果类型：

期刊论文

作者：

Wang, Ningning;Song, Liran;Xing, Hang;Zhang, Ke;Yang, Ronghua;...

通讯作者：

Li, Jishan

作者机构：

[Zhang, Ke; Song, Liran; Wang, Ningning; Li, Jishan; Xing, Hang] Hunan Univ, Coll Chem & Chem Engn, Inst Chem Biol & Nanomed, State Key Lab Chemo Biosensing & Chemometr, Changsha 410082, Hunan, Peoples R China.

[Yang, Ronghua] Changsha Univ Sci & Technol, Sch Chem & Biol Engn, Changsha 410114, Hunan, Peoples R China.

[Zhang, Ke] Northeastern Univ, Dept Chem & Chem Biol, 360 Huntington Ave, Boston, MA 02115 USA.

通讯机构：

[Li, Jishan] H

Hunan Univ, Coll Chem & Chem Engn, Inst Chem Biol & Nanomed, State Key Lab Chemo Biosensing & Chemometr, Changsha 410082, Hunan, Peoples R China.

语种：

英文

关键词：

Gold nanoparticles;Histology;Nanoprobes;Nucleic acids;Tissue;Activity assays;Ex-vivo;Living cell;RNase H;Spherical nucleic acids;Two photon;Photons;DNA;fluorescent dye;gold;metal nanoparticle;ribonuclease H;RNA;animal;chemistry;confocal microscopy;enzymology;Hep-G2 cell line;human;liver;metabolism;photon;photon correlation spectroscopy;rat;Animals;DNA;Dynamic Light Scattering;Fluorescent Dyes;Gold;Hep G2 Cells;Humans;Liver;Metal Nanoparticles;Microscopy, Confocal;Photons;Rats;Ribonuclease H;RNA

期刊：

Nanoscale

ISSN：

2040-3364

年：

2019

卷：

期：

页码：

8133-8137

DOI：

10.1039/c9nr00880b

基金类别：

This work was supported by the NSFC (21775035, 21475036, 21527810) and the Hunan Provincial Natural Science Foundation (2016JJ1005). The authors also thank Professor Chad Mirkin at Northwestern University for his helpful suggestions.

机构署名：

本校为其他机构

院系归属：

化学与生物工程学院

摘要：

We report here a two-photon nanoprobe for the detection of RNase H activity in living cells and ex vivo tissues by combining a two-photon dye with a spherical nucleic acid (SNA) featuring a DNA/RNA duplex corona...

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A spherical nucleic acid-based two-photon nanoprobe for RNase H activity assay in living cells and tissues

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