Facile construction of mitochondria-targeting nanoparticles for enhanced phototherapeutic effects

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成果类型：

期刊论文

作者：

Liu, Yi;Li, Heping*;Xie, Jin;Zhou, Mengxue;Huang, Hui;...

通讯作者：

Li, Heping;Chen, Jun;Hu, Yi

作者机构：

[Liu, Yi; Li, Heping] Changsha Univ Sci & Technol, Hunan Prov Key Lab Mat Protect Elect Power & Tran, Key Lab Rd Struct & Mat, Minist Transport, Changsha 410114, Hunan, Peoples R China.

[Hu, Yi; Liu, Yi; Huang, Hui; Lu, Huiru; Chai, Zhifang; Chen, Jun; Zhou, Mengxue; Hu, Y; Xie, Jin] Chinese Acad Sci, Inst High Energy Phys, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Multidisciplinary Res Div, Beijing 100049, Peoples R China.

[Huang, Hui; Zhou, Mengxue] Univ Chinese Acad Sci, Beijing 100049, Peoples R China.

通讯机构：

[Li, Heping; Chen, J; Hu, Y] C

Changsha Univ Sci & Technol, Hunan Prov Key Lab Mat Protect Elect Power & Tran, Key Lab Rd Struct & Mat, Minist Transport, Changsha 410114, Hunan, Peoples R China.

Chinese Acad Sci, Inst High Energy Phys, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Multidisciplinary Res Div, Beijing 100049, Peoples R China.

语种：

英文

期刊：

BIOMATERIALS SCIENCE

ISSN：

2047-4830

年：

2017

卷：

期：

页码：

1022-1031

DOI：

10.1039/c6bm00878j

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21574136, 21304098, 11375213, 21390411]; CAS Youth Innovation Promotion Association Program [2015008]; Hundred Talents Program of CASChinese Academy of Sciences

机构署名：

本校为第一且通讯机构

院系归属：

交通运输工程学院

化学与生物工程学院

摘要：

Phototherapy, as a noninvasive therapeutic procedure, has been applied to treat tumors. However, the application of phototherapy is often compromised by its low efficiency. Herein, we developed a novel nanoplatform based on cationic amphiphilic polymer-wrapped carbon nanotubes (rPAA@SWCNTs) with a photosensitizer, indocyanine green (ICG), for phototherapy. The as-prepared nanoparticles exhibited excellent mitochondria targeting due to the synergistic properties of highly positive charges from the polycations on the corona and the high hydrophobicity from the carbon nanotubes in the core. Moreo...

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Facile construction of mitochondria-targeting nanoparticles for enhanced phototherapeutic effects

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