Multiple-Armed Tetrahedral DNA Nanostructures for Tumor-Targeting, Dual-Modality in Vivo Imaging

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成果类型：

期刊论文

作者：

Jiang, Dawei;Sun, Yanhong*;Li, Jiang;Li, Qian;Lv, Min;...

通讯作者：

Sun, Yanhong;Zhang, Lan;Wang, Lihua

作者机构：

[Huang, Qing; Zhu, Bing; Sun, Yanhong; Zhang, Lan; Lv, Min; Li, Qian; Tian, Tian; Zhang, L; Wang, Lihua; Li, Jiang; Jiang, Dawei; Fan, Chunhai] Chinese Acad Sci, Div Phys Biol, Shanghai 201800, Peoples R China.

[Huang, Qing; Zhu, Bing; Sun, Yanhong; Zhang, Lan; Lv, Min; Li, Qian; Tian, Tian; Zhang, L; Wang, Lihua; Li, Jiang; Jiang, Dawei; Fan, Chunhai] Chinese Acad Sci, Shanghai Inst Appl Phys, CAS Key Lab Interfacial Phys & Technol, Bioimaging Ctr, Shanghai 201800, Peoples R China.

[Cheng, Dengfeng] Fudan Univ, Zhongshan Hosp, Dept Nucl Med, Shanghai 200032, Peoples R China.

[Xia, Jiaoyun] Changsha Univ Sci & Technol, Sch Chem & Biol Engn, Changsha 410004, Hunan, Peoples R China.

[Shi, Jiye] UCB Pharma, Slough SL1 14EN, Berks, England.

通讯机构：

[Sun, YH; Zhang, L; Wang, LH] C

Chinese Acad Sci, Div Phys Biol, Shanghai 201800, Peoples R China.

Chinese Acad Sci, Shanghai Inst Appl Phys, CAS Key Lab Interfacial Phys & Technol, Bioimaging Ctr, Shanghai 201800, Peoples R China.

语种：

英文

关键词：

tetrahedral DNA nanostructures;tumor targeting;dual-modality imaging;single-photon emission computed tomography;near-infrared fluorescence

期刊：

ACS Applied Materials & Interfaces

ISSN：

1944-8244

年：

2016

卷：

期：

页码：

4378-4384

DOI：

10.1021/acsami.5b10792

基金类别：

Ministry of Science and Technology of ChinaMinistry of Science and Technology, China [2012CB825805, 2012CB932603, 2013CB933802]; National Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21390414, 21227804, 91313302, 61378062, U1232114, 21329501, 31371015, 11405013, 11575278, 21505148]; Shanghai Municipal Commission for Science and Technology [13NM1402300]; Strategic Leading Science & Technology Program [XDA 02030000]; Youth Innovation Promotion Association, CAS

机构署名：

本校为其他机构

院系归属：

化学与生物工程学院

摘要：

In this work, we have developed multiple-armed DNA tetrahedral nanostructures (TDNs) for dual-modality in vivo imaging using near-infrared (NIR) fluorescence and single-photon emission computed tomography (SPECT). We found that the presence of arm strands in TDNs remarkably enhanced their in vitro stability, allowing them to stay intact for at least 12 h in serum. By using NIR fluorescence imaging, we evaluated in mice the pharmacokinetics of TDNs, which exhibited distinctly different in vivo biodistribution patterns compared with those of doub...

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Multiple-Armed Tetrahedral DNA Nanostructures for Tumor-Targeting, Dual-Modality in Vivo Imaging

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