BS-virus-finder: virus integration calling using bisulfite sequencing data

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成果类型：

期刊论文

作者：

Gao, Shengjie;Hu, Xuesong;Xu, Fengping;Gao, Changduo;Xiong, Kai;...

通讯作者：

Pedersen, Christian N. S.;Bolund, Lars

作者机构：

[Pedersen, Christian N. S.; Gao, Shengjie] Aarhus Univ, Bioinformat Res Ctr, CF Mollers Alle 8, DK-8000 Aarhus C, Denmark.

[Hu, Xuesong; Zhao, Xiao; Fu, Dongke; Li, Bo; Li, Shengbin; Gao, Shengjie] BGI Shenzhen, FGI, Shenzhen 518083, Guangdong, Peoples R China.

[Hu, Xuesong; Yang, Huangming; Wang, Jian; Chen, Haixiao; Zhao, Shancen; Li, Bo; Mao, Likai; Wang, Mengyao; Gao, Shengjie; Bai, Jie; Xu, Fengping] BGI Shenzhen, Shenzhen 518083, Guangdong, Peoples R China.

[Gao, Changduo] Qingdao Univ, Coll Comp Sci & Technol, Qingdao 266071, Peoples R China.

[Zhao, Xiaohui; Xiong, Kai] Univ Copenhagen, Dept Vet Clin & Anim Sci, Gronnegardsvej 15, DK-1870 Frederiksberg C, Denmark.

通讯机构：

[Pedersen, Christian N. S.; Bolund, Lars] A

Aarhus Univ, Bioinformat Res Ctr, CF Mollers Alle 8, DK-8000 Aarhus C, Denmark.

Aarhus Univ, Dept Biomed, Bartholins Alle 6, DK-8000 Aarhus C, Denmark.

语种：

英文

关键词：

*bisulfite sequencing;*carcinogenesis;*virus integration

期刊：

GigaScience

ISSN：

2047-217X

年：

2018

卷：

期：

页码：

1-7

DOI：

10.1093/gigascience/gix123

基金类别：

This work was funded by the National Natural Science Foundation of China (81602477) and Shenzhen Municipal Government of China (ZDSYS201507301424148).

机构署名：

本校为其他机构

院系归属：

数学与统计学院

摘要：

Background: DNA methylation plays a key role in the regulation of gene expression and carcinogenesis. Bisulfite sequencing studies mainly focus on calling single nucleotide polymorphism, different methylation region, and find allele-specific DNA methylation. Until now, only a few software tools have focused on virus integration using bisulfite sequencing data. Findings: We have developed a new and easy-to-use software tool, named BS-virus-finder (BSVF, RRID:SCR 015727), to detect viral integration breakpoints in whole human genomes. The tool is...

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