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Safety assessment of a new multivitamin

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成果类型:
期刊论文
作者:
Tao, Jun*;Kong, Hai-wen;Wang, Yan;Cheng, Yun-hui;Shu, Xiao-shun;...
通讯作者:
Tao, Jun
作者机构:
[Shu, Xiao-shun; Cheng, Yun-hui; Yang, Xue-feng; Tao, Jun; Kong, Hai-wen; Tan, Bi-jun; Wang, Yan] Changsha Univ Sci & Technol, Sch Chem & Bioengn, Changsha 410004, Hunan, Peoples R China.
[Tao, Jun] Changsha Univ Sci & Technol, Sch Chem & Bioengn, 960 So Wanjiali Rd, Changsha 410004, Hunan, Peoples R China.
通讯机构:
[Tao, Jun] C
Changsha Univ Sci & Technol, Sch Chem & Bioengn, 960 So Wanjiali Rd, Changsha 410004, Hunan, Peoples R China.
语种:
英文
关键词:
Multivitamin;Acute toxicity;Chronic toxicity;Safety assessment;Toxicology evaluation
期刊:
Food and Chemical Toxicology
ISSN:
0278-6915
年:
2012
卷:
50
期:
5
页码:
1776-1780
基金类别:
This study was supported by the Science and Technology Planning Project of Hunan Province, China (No. 2009SK3005 ).
机构署名:
本校为第一且通讯机构
院系归属:
化学与生物工程学院
摘要:
A newly created multivitamin possesses many protective health functions. To investigate its safety when applied in medical treatment and when used as a food supplement, we studied its acute oral toxicity and 13-week oral toxicity in mice. The results showed that the oral lethal dose, 50% (LD 50) of the biomass of the multivitamin in mice was greater than 2492mg/kg body weight (BW) and that poisoned mice recovered within 72h. The no observed effect level (NOEL) of long-term consumption was more than 249.3mg/kg BW for haematological parameters, c...

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