期刊论文

Liu, Chang(21144@hnie.edu.cn);Yang, Hai(yanghai1001@163.com);Zou, Guoqiang(gq-zou@csu.edu.cn)

英文

Analytical and Bioanalytical Chemistry

1618-2642

2022

414

20

6167-6175

10.1007/s00216-022-04183-4

Financial support from the Scientific Research Fund of Hunan Provincial Education Department (21C0566, 21A0455), the Natural Science Foundation of Hunan Province (2020JJ2012), the National Natural Science Foundation of China (81874332), and the Natural Science Foundation of Hunan Province, China (2020JJ5593).

本校为其他机构

The accurate and sensitive detection of survivin mRNA is of great significance for cancer diagnosis and treatment. However, limited by the low-abundance mRNA in live cells, most strategies of survivin mRNA detection that were one-to-one signal-triggered model (one target triggered one signal) were inapplicable in practice. Here, we reported a binding-induced DNAzyme motor triggered by the survivin mRNA, which was a one-to-more signal-triggered model (one target triggered more signals), amplifying the detection signal and enhancing the sensitivi...