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Visualizing Endogenous Sulfur Dioxide Derivatives in Febrile-Seizure-Induced Hippocampal Damage by a Two-Photon Energy Transfer Cassette

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成果类型:
期刊论文
作者:
Yang, Sheng;Wen, Xidan;Yang, Xiaoguang;Li, Yuan;Guo, Chongchong;...
通讯作者:
Yang, Ronghua
作者机构:
[Wen, Xidan; Yang, Sheng; Yang, Xiaoguang; Guo, Chongchong; Yang, Ronghua; Zhou, Yibo; Li, Heping] Changsha Univ Sci & Technol, Sch Chem & Biol Engn, Hunan Prov Key Lab Mat Protect Elect Power & Tran, Changsha 410114, Hunan, Peoples R China.
[Li, Yuan] Hunan Univ, Coll Chem & Chem Engn, State Key Lab Chemo Biosensing & Chemometr, Changsha 410082, Hunan, Peoples R China.
通讯机构:
[Yang, Ronghua] C
Changsha Univ Sci & Technol, Sch Chem & Biol Engn, Hunan Prov Key Lab Mat Protect Elect Power & Tran, Changsha 410114, Hunan, Peoples R China.
语种:
英文
期刊:
Analytical Chemistry
ISSN:
0003-2700
年:
2018
卷:
90
期:
24
页码:
14514-14520
基金类别:
This work was financially supported by the NSFC (21505006, 21735001, 21575018), the Foundation for Innovative Research Groups of NSFC (21521063), the Hunan Provincial Natural Science Foundation of China (2017JJ3332), and the Scientific Research Fund of Hunan Provincial Education Department (16C0033, 17A002). The authors thank Professor Zhihong Liu of Wuhan University and Dr Wei Liu of Hunan University for their assistance with two photon measurement and tissue preparation, respectively.
机构署名:
本校为第一且通讯机构
院系归属:
化学与生物工程学院
摘要:
Febrile seizure (FS), a frequently encountered seizure disorder in pediatric populations, can cause hippocampus damage. It has been elucidated that sulfur dioxide (SO2) content is overproduced during the development of FS and related brain injury. Thus, monitoring in situ the level of endogenous SO2 in FS-related models is helpful to estimate the pathogenesis of FS-induced brain injury, but the effect detection method remains to be explored. Herein, we developed a two-photon energy transfer cassette based on an acedan-anthocyanidin scaffold, TP...

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