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Evolving a Unique Red-Emitting Fluorophore with an Optically Tunable Hydroxy Group for Imaging Nitroreductase in Cells, in Tissues, and in Vivo.

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成果类型:
期刊论文
作者:
Peng, Rong;Yuan, Jie;Cheng, Dan;Ren, Tianbing;Jin, Fangping;...
通讯作者:
Yuan, Lin
作者机构:
[Zhang, Xiaobing; Ren, Tianbing; Yuan, Lin; Yuan, Jie; Jin, Fangping; Cheng, Dan; Peng, Rong] Hunan Univ, Coll Chem & Chem Engn, State Key Lab Chemobiosensing & Chemometr, Changsha 410082, Hunan, Peoples R China.
[Yang, Ronghua] Changsha Univ Sci & Technol, Sch Chem & Biol Engn, Changsha, Hunan, Peoples R China.
通讯机构:
[Yuan, Lin] H
Hunan Univ, Coll Chem & Chem Engn, State Key Lab Chemobiosensing & Chemometr, Changsha 410082, Hunan, Peoples R China.
语种:
英文
期刊:
Analytical Chemistry
ISSN:
0003-2700
年:
2019
卷:
91
期:
24
页码:
15974-15981
基金类别:
NSFCNational Natural Science Foundation of China [21622504, 21877029, 21735001, 21904035]; Science and Technology Project of Hunan Province [2017RS3019]; China Postdoctoral Science FoundationChina Postdoctoral Science Foundation [2018M642968]
机构署名:
本校为其他机构
院系归属:
化学与生物工程学院
摘要:
Fluorescence molecular imaging has attracted increasing attention due to its various advantages. Lots of fluorophores have been developed to meet various molecular imaging needs. However, it is still inconvenient due to the lack of excellent fluorophores with an optically tunable group for biological molecular imaging. Here a new platform of a versatile long wavelength fluorophore with an optically tunable hydroxyl group was successfully developed by regulating molecular planarity and the twisted intramolecular charge transfer effect with a protected and deprotected hydroxyl group approach via...

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