Triplex-Functionalized DNA Tetrahedral Nanoprobe for Imaging of Intracellular pH and Tumor-Related Messenger RNA.

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成果类型：

期刊论文

作者：

Zhu, Cong;Yang, Jinfeng;Zheng, Jing*;Chen, Shiya;Huang, Fujian*;...

通讯作者：

Zheng, Jing;Huang, Fujian

作者机构：

[Zheng, Jing; Zhu, Cong; Chen, Shiya] Hunan Univ, Coll Chem & Chem Engn, State Key Lab Chemo Biosensing & Chemometr, Changsha 410082, Hunan, Peoples R China.

[Huang, Fujian] China Univ Geosci, Fac Mat Sci & Chem, Minist Educ, Engn Res Ctr Nanogeomat, Wuhan 430074, Hubei, Peoples R China.

[Yang, Ronghua] Changsha Univ Sci & Technol, Sch Chem & Biol Engn, Changsha 410076, Hunan, Peoples R China.

[Yang, Jinfeng] Cent S Univ, Hunan Canc Hosp, Affiliated Canc Hosp, Xiangya Sch Med, Changsha 410083, Hunan, Peoples R China.

通讯机构：

[Zheng, Jing] H

[Huang, Fujian] C

Hunan Univ, Coll Chem & Chem Engn, State Key Lab Chemo Biosensing & Chemometr, Changsha 410082, Hunan, Peoples R China.

China Univ Geosci, Fac Mat Sci & Chem, Minist Educ, Engn Res Ctr Nanogeomat, Wuhan 430074, Hubei, Peoples R China.

语种：

英文

期刊：

Analytical Chemistry

ISSN：

0003-2700

年：

2019

卷：

期：

页码：

15599-15607

DOI：

10.1021/acs.analchem.9b03659

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China [21775037, 21735001, 21974127, 81570572]; Hunan Natural Science FoundationNatural Science Foundation of Hunan Province [2018JJ3032]

机构署名：

本校为其他机构

院系归属：

化学与生物工程学院

摘要：

A new triplex-functionalized DNA tetrahedral nanoprobe is proposed herein for monitoring pH and messenger RNA (mRNA) in living cells. Different from traditional DNA tetrahedron-based nanoprobes, DNA triplex was employed to serve as important conformational conversion elements. Inspired by the low extracellular pH in tumor cells, the mRNA-targeted H1 and H2 were stably assembled on the extended short hairpin probes of DNA tetrahedron via Hoogsteen bonding to form DNA triplex. Due to the high intracellular pH and presence of target mRNA, hybridization chain reaction (HCR) was triggered between H...

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Triplex-Functionalized DNA Tetrahedral Nanoprobe for Imaging of Intracellular pH and Tumor-Related Messenger RNA.

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