Rigidity-Dependent Emission: Inspired Selection of an ATP-Specific Polyvalent Hydrogen Binding-Lighted Fluorophore for Intracellular Amplified Imaging

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成果类型：

期刊论文

作者：

Zhou, Yibo;Ma, Xiaofei;Hu, Shan;Yang, Sheng;Guo, Jingru;...

通讯作者：

Qing, ZH;Yang, RH

作者机构：

[Li, Junbin; Ma, Xiaofei; Qing, Zhihe; Zhang, Yue-Fei; Zhou, Yibo; Hu, Shan] Changsha Univ Sci & Technol, Sch Chem & Chem Engn, Hunan Prov Key Lab Cytochem, Hunan Prov Key Lab Mat Protect Elect Power & Trans, Changsha 410114, Peoples R China.

[Yang, Sheng; Yang, Ronghua] Hunan Normal Univ, Coll Chem & Chem Engn, Lab Chem Biol & Tradit Chinese Med Res, Minist Educ, Changsha 410081, Peoples R China.

[Guo, Jingru] China Pharmaceut Univ, Dept Pharmaceut Anal, State Key Lab Nat Med, Key Lab Drug Qual Control & Pharmacovigilance, Nanjing 210009, Peoples R China.

[Liu, Juewen] Univ Waterloo, Waterloo Inst Nanotechnol, Dept Chem, Waterloo, ON N2L 3G1, Canada.

通讯机构：

[Qing, ZH ] C

[Yang, RH ] H

Changsha Univ Sci & Technol, Sch Chem & Chem Engn, Hunan Prov Key Lab Cytochem, Hunan Prov Key Lab Mat Protect Elect Power & Trans, Changsha 410114, Peoples R China.

Hunan Normal Univ, Coll Chem & Chem Engn, Lab Chem Biol & Tradit Chinese Med Res, Minist Educ, Changsha 410081, Peoples R China.

语种：

英文

期刊：

Analytical Chemistry

ISSN：

0003-2700

年：

2023

卷：

期：

页码：

8318-8324

DOI：

10.1021/acs.analchem.3c00759

基金类别：

National Natural Science Foundation of China [22222402, 22074008, 21974013, 32001782, 22204008]; Changsha Municipal Natural Science Foundation [kq2208216]; Open Fund of State Key Laboratory of Chemo/Biosensing and Chemometrics of Hunan University [2021018]; Open Project of State Key Laboratory of Supramolecular Structure and Materials [sklssm2022015]

机构署名：

本校为第一且通讯机构

院系归属：

化学与生物工程学院

摘要：

ATP,a small molecule with high intracellular concentration (mMlevel), provides a fuel to power signal amplification, which is meaningfulfor biosensing. However, traditional ATP-powered amplification isbased on ATP/aptamer recognition, which is susceptible to the complexbiological microenvironment (e.g., nuclease). In this work, we communicatea signaling manner termed as ATP-specific polyvalent hydrogen binding(APHB), which is mimetic to ATP/aptamer binding but can avoid interferencefrom biomolecules. The key in APHB is a functional fluorophore thatcan selectively bind with ATP via polyvalent h...

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Rigidity-Dependent Emission: Inspired Selection of an ATP-Specific Polyvalent Hydrogen Binding-Lighted Fluorophore for Intracellular Amplified Imaging

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