Quinoxaline-3-carboxylates and analogues are prevalent key structural motifs in bioactive natural products and synthetic drugs. However, the practical protocol for preparation of these motifs from simple raw materials under mild conditions remains rare. In this article, we report a facile protocol for the efficient preparation of various quinoxaline-3-carbonyl compounds (30 examples, 63%–92%) through oxidation coupling of quinoxalin-2(1H)-ones with readily available carbazates (or acyl hydrazines) in the presence of K 2 S 2 O 8 as an oxidant i...