Chitosan oligosaccharide-based dual pH responsive nano-micelles for targeted delivery of hydrophobic drugs.

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期刊论文

作者：

Wang, Yulong*;Khan, Avik;Liu, Yanxin;Feng, Jing;Dai, Lei;...

通讯作者：

Wang, Yulong;Ni, Yonghao

作者机构：

[Wang, Yulong; Liu, Yanxin] Changsha Univ Sci & Technol, Sch Chem & Food Engn, Changsha 410004, Hunan, Peoples R China.

[Ni, Yonghao; Wang, Yulong; Liu, Yanxin; Dai, Lei; Feng, Jing; Alam, Nur; Khan, Avik; Wang, Guanhua; Tong, Li] Univ New Brunswick, Dept Chem Engn, Fredericton, NB E3B 5A3, Canada.

[Feng, Jing] Beijing Inst Petrochem Technol, Coll Chem Engn, Beijing 102617, Peoples R China.

[Dai, Lei] Shaanxi Univ Sci & Technol, Coll Bioresources Chem & Mat Engn, Xian 710021, Shaanxi, Peoples R China.

[Ni, Yonghao] POB 4400, Fredericton, NB E3B 5A3, Canada.

通讯机构：

[Wang, Yulong] C

[Ni, Yonghao] P

Changsha Univ Sci & Technol, Sch Chem & Food Engn, Changsha 410004, Hunan, Peoples R China.

POB 4400, Fredericton, NB E3B 5A3, Canada.

语种：

英文

关键词：

Chitosan oligosaccharide;Drug delivery;Dual pH responsive nano-micelles (DPRNs);Genistein;Nano-micelles

期刊：

Carbohydrate Polymers

ISSN：

0144-8617

年：

2019

卷：

223

页码：

115061

DOI：

10.1016/j.carbpol.2019.115061

基金类别：

The authors gratefully acknowledge the financial support of the Canada Research Chairs Program of the Government of Canada (No. CRC 950213263 ).

机构署名：

本校为第一且通讯机构

摘要：

In this study, chitosan oligosaccharide (COS)-vanillin imine (COS-Vani Imine)-based dual pH responsive nanomicelles (DPRNs) were synthesized. The resultant DPRNs were used for encapsulating genistein and its ultimate release upon pH change. The overall concept of DPRNs for the targeted delivery of hydrophobic anticancer drugs was successfully demonstrated. The DPRNs were spherical in shape, nanoscale in dimension (71.2-163.4 nm), with dual pH response. The encapsulation/loading of genistein into DPRNs was achieved and the resultant genistein-loaded DPRNs were stable under the physiological pH ...

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Chitosan oligosaccharide-based dual pH responsive nano-micelles for targeted delivery of hydrophobic drugs.

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