期刊论文

Zhou, J

中文

有机化学

0253-2786

2023

43

7

2368-2390

10.6023/cjoc202211018

National Natural Science Foundation of China [21801023]; Changsha Municipal Science and Technology Project [kq2004070]; Hunan Provincial Key Laboratory of Materials Protection for Electric Power and Transportation [2020CL03]

本校为第一且通讯机构

多氯代烃在有机合成和化学工业,特别是制药和材料领域中尤其重要,引起了化学家们的广泛关注,诞生了各种合成氯代有机化合物的方法.引入多氯烷基能够作为关键成分改变化合物的药物活性,同时,多氯烷基可以作为前体转化为醛、酮和羧酸等具有不同功能性的官能团,为实现天然产物的后期合成和修饰提供强有力的支持.通过断裂多氯烷烃中的C—H键来构建多氯代化合物的策略,由于具有高步骤经济性,已成为化学家们的研究热点,取得了重要的研究进展.总结了利用二氯甲烷、三氯甲烷作为多氯烷基的前体,从不同的反应体系（过渡金属催化、可见光介导、无金属参与）出发,综述了近十年来基于C—H键断裂策略的多氯烷...

Polychlorinated hydrocarbons are particularly important in organic synthesis and chemical industries, especially in the fields of pharmaceuticals and materials, which have attracted wide attention of chemists and given birth to various methods for the synthesis of chlorinated organic compounds. The introduction of polychloroalkyl can be used as key component to change the drug activity of the compound. At the same time, polychloroalkyl can be used as precursors to transform into aldehydes, ketones, carboxylic acids and other functional groups with different functions, providing strong support ...