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A fluorescent probe based on modulation of ESIPT signaling for the highly selective detection of N2H4 and cell-imaging

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成果类型:
期刊论文
作者:
Zhou, Guoqiang;Ma, Pan;Yang, Can;Xia, Jiaoyun;Gong, Fuchun;...
通讯作者:
Gong, FC
作者机构:
[Gong, Fuchun; Qin, Xiaoling; Yang, Can; Zhou, Guoqiang; Ma, Pan; Chen, Lusen; Qian, You; Gong, FC; Xia, Jiaoyun; Xu, Lujie] Changsha Univ Sci & Technol, Coll Chem & Chem Engn, Changsha 410114, Peoples R China.
通讯机构:
[Gong, FC ] C
Changsha Univ Sci & Technol, Coll Chem & Chem Engn, Changsha 410114, Peoples R China.
语种:
英文
关键词:
Fluorescence imaging;Hydrazine detection;Recognition-driven;inter-ESPT reaction
期刊:
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
ISSN:
1386-1425
年:
2023
卷:
303
页码:
123233
基金类别:
Research Foundation of Education Bureau of Hunan Province [18A141]; State Key Laboratory of Bio-organic and Natural Product Chemistry [SKLBNPC19250]
机构署名:
本校为第一且通讯机构
院系归属:
化学与生物工程学院
摘要:
The broad occurrence of the hydrazine (N(2)H(4)) residues in aqueousenvironment is a potential threat to human health. Currently, the mainstream strategy for designing N(2)H(4)-specific probes is to functionalize a fluorophore with nucleophilic sites for the reductionreaction with N(2)H(4). In this work, we designed and synthesized an excited-state intermolecular proton transfer (inter-ESPT) fluorescent dye(2-amino-4-(4-methoxyphenyl)-7,8-dihydro-5H-spiro[quinoline-6,2'-[1,3]dioxolane]-3-carbonitrilem, DQN) and used it as a probe to sense N(2)H(4). DQN exhibits blue fluorescence in conventiona...

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