Currently, the mainstream strategy for NO 2 − sensing is the use of amino group as the recognition site and Griess reaction as signaling. However, this method suffers from the shortcomings of relying on strong acidic media and being susceptible to interference from amino species. Herein,we synthesized a novel fluorescent probe (OHQ) for NO 2 − . OHQ possesses a methylene activated by cyano group, enabling it to easily react with NO 2 − in a neutral medium. With the addition of NO 2 − , the fluorescence intensity of OHQ is significantly que...