The stress state of finished bridge and service stage is influenced by various closure schemes in cantilever construction of multi-span prestressed concrete box-girder bridge. Two typical bridges multi-span prestressed concrete continuous rigid frame bridge and girder bridge are investigated, The stress state in different closure schemes are analyzed using finite element(FE) analysis. Meanwhile, compared the healthy monitoring data, it has been found that taking the closure sequence from side span to middle span in cantilever construction of multi-span prestressed concrete box-girder bridge ca...