Hypoxia-responsive fluorescent nanoprobe for imaging and cancer therapy

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成果类型：

期刊论文

作者：

Chen, Shiya;Liu, Jin;Li, Yinhui*;Wu, Xu*;Yuan, Quan;...

通讯作者：

Zheng, Jing;Wu, Xu;Li, Yinhui

作者机构：

[Yuan, Quan; Zheng, Jing; Liu, Jin; Chen, Shiya] Hunan Univ, Coll Chem & Chem Engn, Inst Chem Biol & Nanomed ICBN, State Key Lab Chemo Biosensing & Chemometr, Changsha 410082, Hunan, Peoples R China.

[Wu, Xu; Liu, Jin] Cent South Univ, Canc Res Inst, NHC Key Lab Carcinogenesis, Changsha 410083, Peoples R China.

[Wu, Xu; Liu, Jin] Cent South Univ, Canc Res Inst, Chinese Minist Educ, Key Lab Carcinogenesis & Canc Invas, Changsha 410083, Peoples R China.

[Wu, Xu; Liu, Jin] Cent South Univ, Sch Basic Med Sci, Changsha 410083, Peoples R China.

[Chen, Shiya; Li, Yinhui] Xiangtan Univ, Coll Chem, Key Lab Green Organ Synth & Applicat Hunan Prov, Key Lab Environm Friendly Chem & Applicat,Minist, Xiangtan 411105, Peoples R China.

通讯机构：

[Zheng, Jing] H

[Wu, Xu] C

[Li, Yinhui] X

Hunan Univ, Coll Chem & Chem Engn, Inst Chem Biol & Nanomed ICBN, State Key Lab Chemo Biosensing & Chemometr, Changsha 410082, Hunan, Peoples R China.

Cent South Univ, Canc Res Inst, NHC Key Lab Carcinogenesis, Changsha 410083, Peoples R China.

语种：

英文

关键词：

Cancer therapy;Fluorescent nanoprobe;Hypoxia;Intracellular imaging;Reductase

期刊：

TRAC-TRENDS IN ANALYTICAL CHEMISTRY

ISSN：

0165-9936

年：

2020

卷：

131

页码：

116010

DOI：

10.1016/j.trac.2020.116010

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21775037, 2180686, 21974119]; Hunan Natural Science FoundationNatural Science Foundation of Hunan Province [2018JJ3032, 2019JJ30020]; State Key Laboratory of Chemo/Biosensing and Chemometrics Foundation [2017005]; Huxiang high-level talent gathering projectinnovative talents [2019RS1005]

机构署名：

本校为其他机构

院系归属：

化学与生物工程学院

摘要：

With the exaggerated growth of solid tumor, the depletion of O-2 in interior cells far exceeds their blood supply, leading to low levels of O-2 in tumor microenvironment (Hypoxia). Low concentration of O-2 often cause many problems in tumor cells, including poor prognosis, increased metastasis and pro-survival changes in gene expression. Thus, developing new imaging strategy for living cells under hypoxic conditions is strongly desirable. In this review, we discuss recent progress in hypoxia-responsive fluorescent nanoprobes for imaging and cancer therapy. First, we describe two basic elements...

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Hypoxia-responsive fluorescent nanoprobe for imaging and cancer therapy

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