期刊论文

[The inhibitory effects of immune sera against two recombinant hybrid antigens on the growth of Plasmodium falciparum in vitro].

Li, Q.

中文

中国寄生虫学与寄生虫病杂志

Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases

1000-7423

1995

13

3

209-213

本校为其他机构

本文初步观察了兔抗两种重组恶性疟复合抗原（C和CAC）的免疫血清对恶性疟原虫的体外抑制作用。实验结果显示：抗C和抗CAC两种免疫血清对疟原虫体外生长均有明显抑制作用，但抗CAC血清的抑制效果更明显（P＜0．05）。抑制程度随培养物中免疫血清浓度的增高及作用时间的延长而增强，其中抗CAC免疫血清在1％、10％和20％浓度时对疟原虫第2增殖周期（72h）的抑制率分别可达15％、54％和82％。免疫血清作用后较多原虫呈现发育不良及裂殖子凝集和成熟原虫退变现象，提示可能与复合抗原中的多个保护性抗原位点所产生的多功能抗体有关。

The inhibitory effects of rabbit immune sera against two recombinant hybrid antigens (C and CAC) of Plasmodium falciparum to the multiplication and development of in vitro cultured P. falciparum parasites were tested. Although both of anti-C and anti-CAC immune sera had inhibitory effect on parasites, the anti-CAC serum showed much greater effect than that of anti-C serum (P < 0.05). The inhibitory capacities in the sera to parasites were enhanced with the increase in the serum concentration as well as with the prolongation of the incubation time of the sera with the parasites. It was shown th...