期刊论文

中文

精细化工中间体

1009-9212

2011

41

1

29-31,48

10.19342/j.cnki.issn.1009-9212.2011.01.008

本校为第一机构

以谷氨酸、氰酸钾为原料,脲丙酸为催化剂,经过亲核加成反应,重结晶纯化得到目标化合物N-氨甲酰谷氨酸.考察了物料配比、反应时间及温度对反应收率和产品稳定性的影响.优化反应条件为:n(谷氨酸):n(氰酸钾)=1:1.2,反应温度控制在60～65℃,盐酸浓度为12 mol/L,此条件下产品的总收率达到87.0%,含量≥192.0%,产品结构经过1H NMR确认.

N-Carbamyl-L-glutamate is an analogue of the intermediate for synthesis of N-acetyl glutamate. N- Carbamyl-L-glutamate was prepared in 87.0% yield （purity≥92.0%）from glutamic acid and potassium cyanate through reduction and recrystallization. Reaction conditions were optimized, and structure of ...