期刊论文

Synthesis of Piracetam

中文

精细化工中间体

1009-9212

2023

53

01

39-41

10.19342/j.cnki.issn.1009-9212.2023.01.008

本校为第一机构

以α-吡咯烷酮为起始原料，经与甲醇钠反应得到吡咯烷酮钠盐■，再与氯乙酸甲酯缩合得到吡咯烷酮乙酸甲酯■，最后经过氨解反应得吡拉西坦■。该制备方法三废少、污染小、效率高、收率高，具有工业化应用前景。

Using 2-pyrrolidone as starting material,pyrrolidone sodium salt(2)was prepared by substitution re⁃action;methyl pyrrolidone acetate(3)was obtained by the condensation reaction of 2;finally piracetam(1)was obtained by the ammonolysis reaction of 3.This preparation metho...MORE Using 2-pyrrolidone as starting material,pyrrolidone sodium salt(2)was prepared by substitution re⁃action;methyl pyrrolidone acetate(3)was obtained by the condensation reaction of 2;finally piracetam(1)was obtained by the ammonolysis reaction of 3.This preparation metho...