Since 1999,the expansion of colleges enrolment has had a profound impact on the economy and society. Most of the previous literature focused on the impact of the expansion of colleges enrolment on the labor market,lacking of research on the impact of macro-economy,especially on the impact of regional innovation ability. Most of the research on education shows that the expansion of university enrollment in a short period of time improves the level of regional human capital,which will have an long time impact on innovation. Based on this assumption,this paper uses the difference-in-differences (...