The Cu-mediated bimetallic catalyst, MW-53(Fe, Cu)-4, was synthesized for the first time via the microwave hydrothermal method. This catalyst demonstrated effective removal of norfloxacin (NOF) through the activation of persulfate (PDS). The MW-53(Fe, Cu)-4 catalyst demonstrated a superior NOF removal efficiency compared to its non-doped counterpart (MW-53(Fe)), with an increase in efficacy from 13.96% to 79.97% within 5 min. Furthermore, the differences and performance improvements in terms of the morphology, specific surface area, pore diameter, and electrochemical performance were analyzed ...