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Antihyperglycemic effects of total flavonoids from Polygonatum odoratum in STZ and alloxan-induced diabetic rats

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成果类型:
期刊论文
作者:
Shu, Xiao-Shun*;Lv, Jin-Hai;Tao, Jun;Li, Guo-Ming;Li, Huai-Den;...
通讯作者:
Shu, Xiao-Shun
作者机构:
[Shu, Xiao-Shun; Tao, Jun; Li, Guo-Ming] Changsha Univ Sci & Technol, Coll Biol & Chem Engn, Dept Bioengn, Changsha 410076, Hunan, Peoples R China.
[Shu, Xiao-Shun] Ind Inst Zhuzhou Natl Level Hi Tech & Ind Dev Zon, Zhuzhou 410076, Peoples R China.
[Lv, Jin-Hai] Huaihua Coll, Dept Biol, Huaihua 418000, Peoples R China.
[Li, Huai-Den] Cent S Univ, Xiangya Hosp 2, Clin Pharm & Pharmacol Inst, Changsha 410011, Hunan, Peoples R China.
[Ma, Ning] Changsha Med Coll, Changsha 410219, Hunan, Peoples R China.
通讯机构:
[Shu, Xiao-Shun] C
Changsha Univ Sci & Technol, Coll Biol & Chem Engn, Dept Bioengn, Changsha 410076, Hunan, Peoples R China.
语种:
英文
关键词:
acarbose;amylase;antidiabetic agent;flavonoid;gliclazide;plant extract;Polygonatum odoratum extract;unclassified drug;animal experiment;animal model;article;controlled study;dose response;drug dose comparison;enzyme inhibition;glucose blood level;glucose tolerance;glycemic control;hyperglycemia;hypoglycemia;insulin blood level;insulin dependent diabetes mellitus;mouse;non insulin dependent diabetes mellitus;nonhuman;plant root;Polygonatum;Polygonatum odoratum;rat;alpha-Amylases;Animals;Diabetes Mellitus, Experimental;Diabetes Mellitus, Type 1;Diabetes Mellitus, Type 2;Diet;Dietary Fats;Flavonoids;Glucose Tolerance Test;Hypoglycemic Agents;Insulin;Mice;Plant Roots;Polygonatum;Rats;Rats, Sprague-Dawley;Reference Standards;Mus;Polygonatum odoratum;Rattus
期刊:
Journal of Ethnopharmacology
ISSN:
0378-8741
年:
2009
卷:
124
期:
3
页码:
539-543
基金类别:
Professor Meiying Xiao
机构署名:
本校为第一且通讯机构
院系归属:
化学与生物工程学院
摘要:
Aim of the study: Total flavonids of Polygonatum(P) odoratum (TFP) were tested for anti-diabetic activity in streptozotocin (STZ)-induced diabetic mice and alloxan-induced diabetic rats. Materials and methods: Rhizoma Polygonati Odorati, well-known Chinese traditional medicine, is widely used for treatment of diverse diseases for example diabetes. In our study, TFP was extracted by 70% ethanol and purified by macroreticular resin. The experiments were designed to detect the anti-diabetic activity of TFP by determination of blood glucose (BG) us...

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