In the present work, we synthesis glycerol ether by the biomass glycerol. Then the blended fuel was prepared with ethanol, gasolines and glycerol ether. In addition, for the oxygen-containing materials, the distance matrix D based on molecular was modified by the sum of the molecular relative bond intensity matrix R-i and the branching parameter g(i). Then the single topological index X and the mixed topological index A were established. The quantitative structure-property relationship (QSPR) of the mixture topological index A and the physicochemical properties of the glycerol ether blended fu...