The antioxidant and anti-hypertension properties of rice peptides following hydrolysis by proteolytic enzymes have been investigated previously, but the anti-inflammatory and immune characteristics have not been fully explored. In this study, we investigated the inhibitory effects of trypsin-derived rice protein hydrolysates (RPHs) on the inflammatory response in LPS-stimulated RAW264.7 macrophages, and probed their underlying molecular mechanisms of action. Moreover, a fraction, RPHs-C-7-3, displayed significant inflammation suppression activi...