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Rice protein hydrolysates (RPHs) inhibit the LPS-stimulated inflammatory response and phagocytosis in RAW264.7 macrophages by regulating the NF-κB signaling pathway

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成果类型:
期刊论文
作者:
Wen, Li;Chen, Yuehua;Zhang, Li;Yu, Huixin*;Xu, Zhou;...
通讯作者:
Cheng, Yunhui;Yu, Huixin
作者机构:
[You, Haixi; Cheng, Yunhui; Xu, Zhou; Wen, Li; Chen, Yuehua] Changsha Univ Sci & Technol, Dept Food & Biol Engn, Coll Chem & Biol Engn, 960,2nd Sect,Wangjiali South Rd, Changsha 410114, Hunan, Peoples R China.
[Zhang, Li; Yu, Huixin; Wen, Li] Jiangsu Inst Nucl Med, Key Lab Nucl Med, Jiangsu Key Lab Mol Nucl Med, Minist Hlth, Wuxi 214063, Jiangsu, Peoples R China.
通讯机构:
[Cheng, Yunhui] C
[Yu, Huixin] J
Changsha Univ Sci & Technol, Dept Food & Biol Engn, Coll Chem & Biol Engn, 960,2nd Sect,Wangjiali South Rd, Changsha 410114, Hunan, Peoples R China.
Jiangsu Inst Nucl Med, Key Lab Nucl Med, Jiangsu Key Lab Mol Nucl Med, Minist Hlth, Wuxi 214063, Jiangsu, Peoples R China.
语种:
英文
期刊:
RSC Advances
ISSN:
2046-2069
年:
2016
卷:
6
期:
75
页码:
71295-71304
基金类别:
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31171672, 31071523]; Key Programs from MOST [2012BAD34B02, 2011BAK10B05, 2012BAD29B05]; Public Program from the General Administration of Quality Supervision [201310128]; Ministry of Health Foundation of China [W201304]
机构署名:
本校为第一且通讯机构
院系归属:
化学与生物工程学院
摘要:
The antioxidant and anti-hypertension properties of rice peptides following hydrolysis by proteolytic enzymes have been investigated previously, but the anti-inflammatory and immune characteristics have not been fully explored. In this study, we investigated the inhibitory effects of trypsin-derived rice protein hydrolysates (RPHs) on the inflammatory response in LPS-stimulated RAW264.7 macrophages, and probed their underlying molecular mechanisms of action. Moreover, a fraction, RPHs-C-7-3, displayed significant inflammation suppression activi...

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