National Natural Science Foundation of China [20501022, 20876016]; Scientific Research Fund of Hunan Provincial Education Department [07A006]; Key Project of Chinese Ministry of Education [208095]
机构署名：
本校为第一且通讯机构
院系归属：
化学与生物工程学院
摘要：
The purpose of this work was to indirect label IgG with fac-[188Re(CO)3(H2O)3]+ and to check the radiochemical behavior of the labeled product. The compound of (bis(2-pyridylmethyl)-amino)-acetic acid (L2H) was synthesized and labeled with fac-[188Re(CO)3(H2O)3]+. The labeling yield of 188Re(CO)3–L2H was more than 90%. The effects of protein concentration, reaction time, pH and reaction temperature of labeling of IgG with 188Re(CO)3–L2H were investigated. The conjugation conditions were optimized. The labeled product was analyzed by size excl...
