PGAGP: Predicting pathogenic genes based on adaptive network embedding algorithm

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成果类型：

期刊论文

作者：

Zhang, Yan;Xiang, Ju;Tang, Liang;Yang, Jialiang;Li, Jianming

通讯作者：

Xiang, J.;Yang, J.;Li, J.

作者机构：

[Zhang, Yan; Xiang, Ju] Cent South Univ, Sch Comp Sci & Engn, Changsha, Peoples R China.

[Zhang, Yan; Xiang, Ju] Changsha Med Univ, Sch Informat Sci & Engn, Changsha, Peoples R China.

[Yang, Jialiang; Li, Jianming; Zhang, Yan; Xiang, Ju; Tang, Liang] Changsha Med Univ, Academician Workstat, Changsha, Peoples R China.

[Xiang, Ju] Changsha Univ Sci & Technol, Sch Comp & Commun Engn, Changsha, Peoples R China.

[Li, Jianming; Xiang, Ju; Tang, Liang] Changsha Med Univ, Dept Basic Med Sci, Changsha, Peoples R China.

通讯机构：

[Xiang, J.] S

[Yang, J.; Li, J.] A

Academician Workstation, China

School of Computer Science and Engineering, China

语种：

英文

关键词：

Disease-gene prediction;biological network;Network embedding;Network propagation;Random projection

期刊：

Frontiers in Genetics

ISSN：

1664-8021

年：

2023

卷：

页码：

1087784

DOI：

10.3389/fgene.2022.1087784

基金类别：

This work was supported by the Training Program for Excellent Young Innovators of Changsha (Grant No. kq2206056, kq2206058), the National Natural Science Foundation of China (Grant No. 81873780), The Foundation of Project of Hunan Health and Family Planning Commission (Grant No. 202202082739), The Foundation of the Education Department of Hunan Province (Grant No. 21A0586), and the Application Characteristic Discipline of Hunan Province.

机构署名：

本校为其他机构

院系归属：

计算机与通信工程学院

摘要：

The study of disease-gene associations is an important topic in the field of computational biology. The accumulation of massive amounts of biomedical data provides new possibilities for exploring potential relations between diseases and genes through computational strategy, but how to extract valuable information from the data to predict pathogenic genes accurately and rapidly is currently a challenging and meaningful task. Therefore, we present a novel computational method called PGAGP for inferring potential pathogenic genes based on an adapt...

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PGAGP: Predicting pathogenic genes based on adaptive network embedding algorithm

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