The finite block method (FEM) is developed to determine stress intensity factors with orthotropic functionally graded materials under static and dynamic loads in this paper. By employing the Lagrange series, the first order partial differential matrix for one block is derived with arbitrary distribution of nodes. The higher order derivative matrix for two dimensional problems can be constructed directly. For linear elastic fracture mechanics, the COD and J-integral techniques to determine the stress intensity factors are formulated. For the dynamic problems, the Laplace transform method and Du...