A facile method for the synthesis of copper-cysteamine nanoparticles and study of ROS production for cancer treatment

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成果类型：

期刊论文

作者：

Pandey, Nil Kanatha;Chudal, Lalit;Phan, Jonathan;Lin, Liangwu;Johnson, Omar;...

通讯作者：

Chen, Wei;Shu, Yang

作者机构：

[Chen, Wei; Johnson, Omar; Pandey, Nil Kanatha; Xing, Meiying; Li, Haibin; Huang, Xuejing; Phan, Jonathan; Liu, J. Ping; Chudal, Lalit] Univ Texas Arlington, Dept Phys, Arlington, TX 76019 USA.

[Lin, Liangwu] Cent S Univ, Lab High Strength Struct Mat, Changsha 410083, Hunan, Peoples R China.

[Li, Haibin] Changsha Univ Sci & Technol, Sch Mat Sci & Engn, Changsha 410114, Hunan, Peoples R China.

[Shu, Yang] Northeastern Univ, Coll Sci, Res Ctr Analyt Sci, Dept Chem, Shenyang 110819, Liaoning, Peoples R China.

通讯机构：

[Chen, Wei] U

[Shu, Yang] N

Univ Texas Arlington, Dept Phys, Arlington, TX 76019 USA.

Northeastern Univ, Coll Sci, Res Ctr Analyt Sci, Dept Chem, Shenyang 110819, Liaoning, Peoples R China.

语种：

英文

关键词：

Cells;Copper;Diseases;Nanoparticles;Oxygen;Photodynamic therapy;Ultrasonic applications;Viruses;Hydroxyl radicals;Probe molecules;Reactive oxygen species;Singlet oxygen;Size reductions;Synthesis time;Tracking agent;Ultraviolet lights;Synthesis (chemical);antineoplastic agent;copper;hydroxyl radical;mercaptamine;metal nanoparticle;photosensitizing agent;reactive oxygen metabolite;singlet oxygen;chemistry;human;metabolism;microwave radiation;neoplasm;radiation response;synthesis;tumor cell line;ultraviolet radiation;Antineoplastic Agents;Cell Line, Tumor;Copper;Cysteamine;Humans;Hydroxyl Radical;Metal Nanoparticles;Microwaves;Neoplasms;Photosensitizing Agents;Reactive Oxygen Species;Singlet Oxygen;Ultraviolet Rays

期刊：

JOURNAL OF MATERIALS CHEMISTRY B

ISSN：

2050-750X

年：

2019

卷：

期：

页码：

6630-6642

DOI：

10.1039/c9tb01566c

基金类别：

We would like to acknowledge the support from the U.S. Army Medical Research Acquisition Activity (USAMRAA) under Contracts of W81XWH-10-1-0279 and W81XWH-10-1-0234 as well as the partial support from NIH/NCI 1R15CA199020-01A1. We are thankful to CytoViva Inc., Auburn, AL, USA, for hyperspectral imaging.

机构署名：

本校为其他机构

院系归属：

材料科学与工程学院

摘要：

Copper-cysteamine (Cu-Cy) is a novel sensitizer that can be excited by ultraviolet (UV) light, microwave (MW), ultrasound, and X-rays to generate highly toxic reactive oxygen species (ROS) for cancer cell destruction. The purpose of this study is to present a facile method for the synthesis of Cu-Cy nanoparticles. Interestingly, we were able to decrease both the stirring and heating time by about 24 and 6 times, respectively, thus making Cu-Cy nanoparticles more economical than what was reported before. 1,4-Diazabicylo[2.2.2]octane (DABCO), a w...

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A facile method for the synthesis of copper-cysteamine nanoparticles and study of ROS production for cancer treatment

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