通讯机构：
[Faxiang Wang; Yongle Liu] H;Hunan Provincial Engineering Technology Research Center of Aquatic Food Resources Processing, School of food science and bioengineering, Changsha University of Science and Technology, Changsha, 410114 China
关键词：
quercitrin;calcineurin;immunity;CN-NFAT signal pathway;interaction
摘要：
Objective This study aimed to search for immunosuppressants with high-efficiency and low-toxicity from Chinese herbal medicine using calcineurin (CN) as the target enzyme. Methods Natural compound which could inhibit the activity of the target enzyme, CN, was screened and one effective compound was identified and isolated. The immunosuppressive effect and toxic side effects of the compound were evaluated at the cellular and animal levels. The underlying immunosuppressive mechanism was explored using fluorescence spectroscopy, molecular docking, Western blot, dual-luciferase reporter gene, real-time PCR, etc. Results Quercitrin inhibited CN activity both in vitro and in vivo. In addtion, it reduced the proliferation of splenocyte and ameliorated DTH symptoms in mice. Toxicological study showed that quercitrin had no or minimal toxic side effects on experimental animals. Fluorescence spectroscopy and molecular docking analysis showed that quercitrin may bind to two sites on the CN and regulate immune responses through the CN-NFAT pathway. Conclusion We identified a new CN inhibitor, quercitrin, which could be a useful novel immunosuppressant with low toxicity.
通讯机构：
[Zhenghua Zhang; Prof. Hongmei Wang] C;College of Chemistry and Chemical Engineering, Changsha University of Science and Technology, Changsha, 410114 Hunan, China<&wdkj&>College of Chemistry and Chemical Engineering, Central South University, Changsha, 410083 Hunan, China
作者机构：
[高海燕; 冯路利; 干庆展; 贺跃辉] State Key Laboratory of Powder Metallurgy, Central South University, Changsha, 410083, China;[喻林萍] School of Chemistry and Biology Engineering, Changsha University of Science & Technology, Changsha, 410114, China
通讯机构：
[Gao, H.] S;State Key Laboratory of Powder Metallurgy, China
摘要：
Stabilization is the most complicated and time-consuming step in the manufacture of carbon fibers (CFs), which is important to prepare CFs with high performance. Accelerated stabilization was successfully demonstrated under effective plasma irradiation-assisted modification (PIM) of mesophase pitch fibers (PFs). The results showed that the PIM treatment could obviously introduce more oxygen-containing groups into PFs, which was remarkably efficient in shortening the stabilization time of PFs with a faster stabilization heating rate, as well as in preparing the corresponding CFs with higher performance. The obtained graphitized fiber (GF-5) from the PF-5 under PIM treatment of 5 min presented a higher tensile strength of 2.21 GPa, a higher tensile modulus of 502 GPa, and a higher thermal conductivity of 920 W/m & BULL;K compared to other GFs. Therefore, the accelerated stabilization of PFs by PIM treatment is an efficient strategy for developing low-cost pitch-based CFs with high performance.
通讯机构：
[Meng-Chang Lin] C;[Donghong Yu] H;Hunan Provincial Key Laboratory of Materials Protection for Electric Power and Transportation, and Hunan Provincial Key Laboratory of Cytochemistry, School of Chemistry and Biological Engineering, Changsha University of Science and Technology, Changsha 410114, China<&wdkj&>Department of Chemistry and Bioscience, Aalborg University, DK-9220 Aalborg, Denmark<&wdkj&>Sino-Danish Center for Education and Research (SDC) Niels Jensens Vej 2, DK-8000 Aarhus, Denmark<&wdkj&>College of Electrical Engineering and Automation, Shandong University of Science and Technology, Qingdao 266590, China
关键词：
Polymer solar cells;Fluorination;Benzothiadiazole;Donor-acceptor;Steric hindrance
摘要：
Three new donor-acceptor (D-A) conjugated polymers based on benzo[1,2-b:4,5-b ']dithiophene (BDT) and benzo [c][1,2,5]thiadiazole (BT), namely, PB-BT, PB-BTf and PB-BTPf, were synthesized with different substituents (Hydrogen atoms, Fluorine atoms and fluorophenyl groups) on BT unit. Experimental results and theoretical calculations indicate that molecularly tuning of side chains on BT moeity simultaneously influences the energy levels and intermolecular packing of the resulted polymers by modulating their electron affinity and molecular coplanarity. The polymer solar cells (PSCs) based on a blend of PB-BTf/[6,6]-phenyl-C71-butyric acid methyl ester (PC71BM) exhibits the best photovoltaic performance among the three copolymers, with a open-circuit voltage (Voc) of 0.79 V and a power conversion efficiency (PCE) of 8.43%. Furthermore, polymer PB-BTPf containing fluorophenyl groups shows a higher Voc of 0.99 V due to its more low-lying highest occupied molecular orbital (HOMO) compared with other two structural polymeric analogues. The results here provide further fundamental insights into the relationship between the fluorination on electron-withdrawing moiety and the photovoltaic performance for the conjugated polymers applied in fullerene organic solar cells.
摘要：
A simple and efficient visible-light-initiated cascade reaction of 2-isothiocyanatonaphthalenes and amines with ambient dioxygen as the sole oxidant under additive-, external photocatalyst-free and ambient conditions was developed. 38 Examples of N-substituted naphtho[2,1-d]thiazol-2-amines were regioselectively constructed in good to excellent yields.
作者机构：
[Cai, Mian; Du, Li; Huang, Baojin; Lin, Meng-Chang] College of Electrical Engineering and Automation, Shandong University of Science and Technology, Qingdao 266590, China;[Cao, Zhong] Hunan Provincial Key Laboratory of Materials Protection for Electric Power and Transportation, and Hunan Provincial Key Laboratory of Cytochemistry, School of Chemistry and Biological Engineering, Changsha University of Science and Technology, Changsha 410114, China;Department of Chemistry and Bioscience, Aalborg University, DK-9220 Aalborg, Denmark;Sino-Danish Center for Education and Research (SDC) Niels Jensens Vej 2, DK-8000 Aarhus, Denmark;[Du, Zhengkun] College of Electrical Engineering and Automation, Shandong University of Science and Technology, Qingdao 266590, China<&wdkj&>Department of Chemistry and Bioscience, Aalborg University, DK-9220 Aalborg, Denmark
通讯机构：
[Donghong Yu] H;Hunan Provincial Key Laboratory of Materials Protection for Electric Power and Transportation, and Hunan Provincial Key Laboratory of Cytochemistry, School of Chemistry and Biological Engineering, Changsha University of Science and Technology, Changsha 410114, China<&wdkj&>Department of Chemistry and Bioscience, Aalborg University, DK-9220 Aalborg, Denmark<&wdkj&>Sino-Danish Center for Education and Research (SDC) Niels Jensens Vej 2, DK-8000 Aarhus, Denmark
摘要：
Three new donor–acceptor (D–A) copolymers based on benzodithiophene (BDT) with alkylthiolated aromatic rings furan, thiophene, and benzene and 5,6-difluoro-4,7-bis(4-(2-octyldodecyl)thiophen-2-yl)benzo[c][1,2,5]thiadiazole (DTBT) units, namely PBDTFS-DTBT, PBDTTS-DTBT, and PBDTPS-DTBT, respectively, were synthesized and applied in solution-processed fullerene type organic solar cells (OSCs). The target polymers were systematically investigated by thermogravimetric analysis (TGA), ultraviolet-visible (UV–vis) absorption spectra, cyclic voltammetry (CV), density functional theory (DFT) and photovoltaic measurements. The experimental results imply that the electron push-pull effect and torsion angles between the conjugated side hetero-aromatic rings and BDT core play a key role in tuning the optical absorption bands, molecular energy levels, hole mobilities, and morphology of the corresponding polymers. The OSCs based on PBDTTS-DTBT and [6,6]-phenyl-C71-butyric acid methyl ester (PC71BM) show the highest power conversion efficiency (PCE) of 7.80% among the three polymeric analogues, with an open-circuit voltage (Voc) of 0.92 V, a short-circuit current density (Jsc) of 11.95 mA cm−2 and fill factor (FF) of 70.76%. Hence, the results in this work indicate that the photovoltaic properties of the BDT-BT-based polymers can be effectively modulated by introducing conjugated alkylthiolated hetero-aromatic rings with the varied electron donating ability and steric hindrance.
摘要：
The design of Ni-rich core and Mn-rich shell is of great significance for improving the electrochemical performance of lithium-ion battery cathode materials at high voltage. The core-shell structure LiNi0.8Co0.1Mn0.1O2 (CS-NCM811) cathode materials is prepared through co-precipitation method. XRD shows that the cathode materials have alpha-NaFeO2 layered structure and SEM images show that the material has a good morphology. The elemental compositions in Ni, Co, and Mn of both the core and shell of the CS-NCM811 particles are analyzed by EDS. The electrochemical performance results show that the CS-NCM811 provides better cycling stability than the homogeneous. The capacity retention rate of CS-NCM811 at 3 C is significantly higher than that of homogeneous materials at 4.6 V. The change in morphology after 100 cycles proves that the core-shell structure can inhibit the side reaction and reduce polarization. In addition, the CS-NCM811 has better thermal stability with high exothermic temperature and low heat.
作者机构：
[Jiang, Si; Lu, Cui-Hong; Li, Jiang-Sheng; Yang, Pan-Pan; Li, Zhi-Wei; Xie, Xin-Yun] Changsha Univ Sci & Technol, Hunan Prov Key Lab Mat Protect Elect Power & Tran, Sch Chem & Food Engn, Changsha 410114, Peoples R China.;[Liu, Wei-Dong] Hunan Res Inst Chem Ind, Natl Engn Res Ctr Agrochem, Changsha 410007, Peoples R China.
通讯机构：
[Li, Jiang-Sheng] C;Changsha Univ Sci & Technol, Hunan Prov Key Lab Mat Protect Elect Power & Tran, Sch Chem & Food Engn, Changsha 410114, Peoples R China.
摘要：
An efficient and facile method for the synthesis of amides from aldehydes with isothiocyanates under reagent-free autoxidative conditions is established. This protocol showcases the capture of carboxylic acids in situ generated through aldehyde autoxidation by isothiocyanates as both coupling mediators and amine surrogates, featuring no use of catalysts, explosive chemical oxidants, and additional activating reagents.
作者：
Yao, Y.;Zhang, J.;Zhou, X. J.;Jiang, L. K.;Peng, P.
期刊：
Transactions of the Indian Institute of Metals,2021年74(12):3171-3184 ISSN：0972-2815
通讯作者：
J. Zhang
作者机构：
[Yao, Y.; Zhou, X. J.; Zhang, J.; Jiang, L. K.] Changsha Univ Sci & Technol, Hunan Prov Key Lab Intelligent Mfg Technol High P, Changsha 410114, Peoples R China.;[Zhang, J.] Changsha Univ Sci & Technol, Sch Chem & Food Engn, Hunan Prov Key Lab Mat Protect Elect Power & Tran, Changsha 410114, Peoples R China.;[Peng, P.] Hunan Univ, Coll Mat Sci & Engn, Changsha 410082, Peoples R China.
通讯机构：
[J. Zhang] H;Hunan Provincial Key Laboratory of Intelligent Manufacturing Technology for High-Performance Mechanical Equipment, Changsha University of Science and Technology, Changsha, China<&wdkj&>Hunan Provincial Key Laboratory of Materials Protection for Electric Power and Transportation, School of Chemistry and Food Engineering, Changsha University of Science and Technology, Changsha, China
摘要：
The filings of magnesium-rich Mg98.5Y1Zn0.5 alloy with different morphologies were prepared by using three kinds of files with arc (A), triangle (T), and flat (F) cross sections, respectively. Their microstructures, hydrogen storage properties, and mechanisms were investigated. The results reveal that these filings all present high storage capacity of about 7.0 wt% and excellent hydrogen sorption kinetics. However, the hydrogen ab/desorption properties of these filings exhibit obvious differences, which is closely related with their microscopic morphologies. Among them, the filings prepared by F file possess the best hydrogen sorption properties due to their higher saw teeth density and more dislocations induced through F file relative to those by A and T files. First-principles calculations reveal that the YH2 not only weakens the H-H and Mg-H bond strength, but also reduces the recombination energy of H atoms from MgH2 surface and the dissociation energy of H-2 molecule on Mg surface during the hydrogenation/dehydrogenation of Mg-Y-Zn alloy.
期刊：
Journal of Alloys and Compounds,2021年881:160667 ISSN：0925-8388
通讯作者：
Dong Qian
作者机构：
[Liu, Jinlong; Long, Xuanda; Zhang, Zhiliang; Su, Kanda; Qian, Dong; Guo, Jiangnan; Xu, Deyao] Cent South Univ, Coll Chem & Chem Engn, Hunan Prov Key Lab Chem Power Resources, Changsha 410083, Peoples R China.;[Li, Junhua] Hengyang Normal Univ, Coll Chem & Mat Sci, Hengyang 421008, Peoples R China.;[Liu, Jinlong] Univ Auckland, Sch Chem Sci, Auckland 1142, New Zealand.;[Tong, Haixia] Changsha Univ Sci & Technol, Inst Chem & Biol Engn, Changsha 410114, Peoples R China.;[Liu, Zeng] Cangzhou Dahua Grp Co Ltd, Cangzhou 061000, Peoples R China.
通讯机构：
[Dong Qian] H;Hunan Provincial Key Laboratory of Chemical Power Resources, College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, PR China
摘要：
We rationally design and construct a heterostructured hybrid with reduced graphene oxide served as a platform to in-situ grow N-doped bamboo-like carbon nanotubes encapsulating bimetallic Co-Fe sulfide nanoparticles through a two-stage pyrolysis succeeded by an evaporating sulfurization process (denoted as CoxFe1-xS2@N-CNTs/rGO). By tuning the Co/Fe ratio, the optimal Co0.6Fe0.4S2@N-CNTs/rGO exhibits a remarkable oxygen evolution reaction (OER) performance in 1.0 M KOH, in which the overpotential at 10 mA cm(-2) and Tafel slope are recorded as 248 mV (vs. RHE) and 58.3 mV dec(-1), respectively, outmaneuvring commercial RuO2 and most Co/Fe sulfide-based catalysts in recent peer reports. Comprehensive experiment results unravel that the outstanding OER electrocatalytic performance owes to the reinforced synergy between CoS2 and FeS2, the heterostructures constituted by partial CoS2 and FeS2, the confining effect of N-CNTs/rGO for CoS2 and FeS2 nanoparticles, and the high conductivity and large surface of N-CNTs/rGO. (C) 2021 Elsevier B.V. All rights reserved.
摘要：
Capric-palmitic acids eutectics (CA-PA)/silica xerogel and CA-PA/silica xerogel/exfoliated graphite nano platelets (xGnP) form-stable phase change materials (PCMs) were prepared via a facile sol-gel method. Characterization of the prepared form-stable PCMs revealed that after incorporating xGnP into the hydrophilic silica xerogel, the loading of the hydrophobic CA-PA in the form-stable PCMs was effectively improved while the thermal conductivity of the form-stable PCMs was significantly enhanced at the same time. The loading of CA-PA in the CA-PA/silica form-stable PCMs with good form-stability could attain 75 wt%, and was further increased to 85 wt% in the CA-PA/silica/xGnP form-stable PCM containing 6 wt% xGnP. The latent heat of the CA-PA/silica and the CA-PA/silica/xGnP form-stable PCMs could attain 103.4 and 123.1 J/g, respectively, and possessed good long-term thermal reliability. The CA-PA/silica form-stable PCM exhibited an exceedingly low thermal conductivity of 0.17 W/mK and a very slow speed of heat storage and releasing, which made it a promising candidate for thermal regulating material. On the other hand, the thermal conductivity of the CA-PA/silica/ xGnP form-stable PCMs was greatly enhanced by xGnP. The thermal conductivity of the CA-PA/silica/xGnP form-stable PCM with 85 wt% CA-PA and 6 wt% xGnP could attain 0.70 W/mK, which was 218% higher than that of CA-PA. The high thermal conductivity also resulted in a higher speed of heat storage and releasing, which was in favor of its application as latent heat storage material for building-comfort control.
通讯机构：
[Mian Chen; Xu Wu] N;[Jing Zheng] S;National-Regional Key Technology Engineering Laboratory for Medical Ultrasound, Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, Health Science Center, School of Biomedical Engineering, Shenzhen University, Shenzhen 518055, China<&wdkj&>NHC Key Laboratory of Carcinogenesis and Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute and School of Basic Medical Science, Central South University, Changsha 410083, China<&wdkj&>State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Institute of Chemical Biology and Nanomedicine (ICBN), Hunan University, Changsha 410082, China
摘要：
The peroxidase-like activity of nanozymes is promising for chemodynamic therapy by catalyzing H2O2 into .OH. However, for most nanozymes, this activity is optimal just in acidic solutions, while the pH of most physiological systems is beyond 7.0 (even >8.0 in chronic wounds) with inadequate H2O2. We herein communicate an activatable nanozyme with targeting capability to simultaneously break the local pH and H2O2 limitations under physiological conditions. As a proof of concept, aptamer-functionalized nanozymes, glucose oxidase, and hyaluronic acid constitute an activatable nanocapsule “APGH”, which can be activated by bacteria-secreted hyaluronidase in infected wounds. Nanozymes bind onto bacteria through aptamer recognition, and glucose oxidation tunes the local pH down and supplements H2O2 for the in-situ generation of .OH on bacteria surfaces. The activity switching and enhanced antibacterial effect of the nanocapsule were verified in vitro and in diabetic wounds. This strategy for directly regulating local microenvironment is generally accessible for nanozymes, and significant for facilitating biological applications of nanozymes.
