摘要：
A simple and efficient visible-light-initiated cascade reaction of 2-isothiocyanatonaphthalenes and amines with ambient dioxygen as the sole oxidant under additive-, external photocatalyst-free and ambient conditions was developed. 38 Examples of N-substituted naphtho[2,1-d]thiazol-2-amines were regioselectively constructed in good to excellent yields.
摘要：
An eco-friendly,sustainable and practical method for the efficient preparation of 5-organylselanyl uracils through the electrochemical selenylation of uracils and dio rganyl diselenides at room temperature under oxidant-and external electrolvte-free conditions was developed.
摘要：
As a primary building block for protein synthesis, L-arginine (L-Arg) is also a precursor for the synthesis of important metabolites, and is involved in various physiological and pathophysiological processes. L-Arg is a potential biomarker in clinical diagnosis and nutritional status assessment, making it valuable to quantify and monitor this biomolecule. In this study, peptide aptamers that specifically interact with L-Arg were identified by high-throughput molecular docking, and the binding capacities between the synthesized peptide aptamers and L-Arg were then measured by isothermal titration calorimetry. We hypothesized that the peptide aptamer with the greatest binding capacity could be used as the recognition element in a biosensor. A chemosynthetic peptide aptamer modified with mercaptan and spacer units (thioctic acid-GGGG-FGHIHEGY) was thus used to construct label-free electrochemical impedimetric biosensors for L-Arg based on gold electrodes. The optimum biosensor showed good sensitivity to L-Arg with a linear range of 0.1 pM-0.1 mM, and the calculated limit of detection (three times the signal-to-noise ratio) was 0.01 pM. Interference studies and assays of diluted serum samples were also carried out, and satisfactory results obtained. In conclusion, a potential method of peptide aptamer screening and biosensor fabrication for detecting small biological molecules was demonstrated. (C) 2020 Elsevier B.V. All rights reserved.
作者机构：
[肖忠良; 周乘风; 宋刘斌; 曹忠; 蒋鹏] Hunan Provincial Key Laboratory of Materials Protection for Electric Power and Transportation, School of Chemistry and Food Engineering, Changsha University of Science and Technology, Changsha;Hunan;410114, China;[肖忠良; 周乘风; 宋刘斌; 曹忠; 蒋鹏] Hunan;[肖忠良; 周乘风; 宋刘斌; 曹忠; 蒋鹏] 410114, China
摘要：
Aerobic oxidation using pure dioxygen gas as the oxidant has attracted much attention,but its application in synthetic chemistry has been significantly hampered by the complexity of catalytic system and potential risk of high-energy dioxygen gas.By employing 1,2-diethoxyethane as a catalyst and ambient air as an oxidant,an efficient protocol for the construction of various aryl-alkyl and diaryl ketones through oxidative cleavage of gem-disubstituted aromatic alkenes under minimal solvent conditions has been achieved.
作者机构：
[肖忠良; 宋刘斌; 曹忠; Zeng C.; 刘佩; 吴道新] Changsha University of Science and Technology, School of Chemistry and Food Engineering, Hunan Provincial Key Laboratory of Materials Protection for Electric Power and Transportation, Changsha, 410114, China
通讯机构：
[Song, L.] C;Changsha University of Science and Technology, China
摘要：
By using ambient air as the oxidant and malic acid as the promoter, a practical method for the preparation of 2-aminobenzothiazoles through visible-light-initiated cascade reaction of aromatic amines and KSCN in eco-friendly bis(methoxypropy)ether under metal-, hazardous additive-, photocatalyst-free conditions was established.
摘要：
A straightforward approach to the fabrication of intrinsically excited-state intramolecular proton transfer (ESIPT)-fluorescent polymer nanoparticles (e-PNPs) was developed. The e-PNPs were obtained by self-assembly of the homopolymers derived from 4-aminosalicylic acid in aqueous solution. By incorporating ESIPT modules into polymer nanoparticles, the ESIPT reaction can be endowed with moderate hydrophobic micro-environment by nanoparticle scaffolds, eliciting enhanced ESIPT emission. The newly developed e-PNPs exhibit strong tautomeric fluorescence(e-FL), good photostability, low-toxicity and favourable biocompatibility in aqueous solution. Upon the addition of NO2(-), the e-FL can be significantly quenched owing to the reaction of NO2(-) with the amide groups on e-PNPs. From this basis, the fluorescence detection of NO2(-) was implemented, which showed a linear relationship between 0nM and 110nM with a detection limit of 2.3nM. Furthermore, e-PNPs were used as nanoprobes to monitor the NO2(-) levels in HeLa cells by fluorescence imaging, demonstrating the ability of discrimination from different concentrations of NO2(-). The proposed method can be applied to a wide range of other ESIPT modules to integrate into polymer nanoparticles and offer highly sensitive nanosensing platform for bioanalysis and molecular imaging.
作者机构：
[Teng, Fan; Gui, Qing-Wen; Liu, Yang; Ying, Sheng-Neng; Guo, Tao] Hunan Agr Univ, Coll Chem & Mat Sci, Changsha 410128, Peoples R China.;[Tang, Jian-Xin] Hunan Univ Technol, Sch Life Sci & Chem, Zhuzhou 412007, Peoples R China.;[He, Wei-Min; Chen, Jin-Yang; Cao, Zhong] Changsha Univ Sci & Technol, Hunan Prov Key Lab Mat Protect Elect Power & Tran, Changsha 410114, Peoples R China.
通讯机构：
[He, Wei-Min] C;Changsha Univ Sci & Technol, Hunan Prov Key Lab Mat Protect Elect Power & Tran, Changsha 410114, Peoples R China.
关键词：
Green chemistry;Solvent-free;Tandem reaction;Dual role;Ultrasound
摘要：
An energy-saving and eco-friendly method for the efficient construction of various tri- and tetra-substituted pyrrolecarbonitriles through ultrasound-assisted multicomponent tandem reaction of readily available alkenes, TMSCN and N,N-disubstituted formamides within 40 min under metal-, solvent-free and mild conditions was developed. The dual role of iodine (catalyst and oxidant) notably simplified the reaction conditions and reduced the chemical waste generated (C) 2020 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
作者机构：
[Wei, Wen-Ting; Huang, Xun-Jie; Liang, Hongze; Liu, Yi; Qin, Fu-Hua] Ningbo Univ, Sch Mat Sci & Chem Engn, State Key Lab Base Novel Funct Mat & Preparat Sci, Ningbo 315211, Peoples R China.;[Li, Qiang] Liaocheng Univ, Sch Chem & Chem Engn, Inst Funct Organ Mol & Mat, Liaocheng 252059, Shandong, Peoples R China.;[He, Wei-Min; Cao, Zhong] Changsha Univ Sci & Technol, Hunan Prov Key Lab Mat Protect Elect Power & Tran, Changsha 410114, Peoples R China.
通讯机构：
[Wei, Wen-Ting] N;[He, Wei-Min] C;Ningbo Univ, Sch Mat Sci & Chem Engn, State Key Lab Base Novel Funct Mat & Preparat Sci, Ningbo 315211, Peoples R China.;Changsha Univ Sci & Technol, Hunan Prov Key Lab Mat Protect Elect Power & Tran, Changsha 410114, Peoples R China.
关键词：
Green chemistry;Metal free;Cyclization;Alcohol;Pyrrolidinone
摘要：
An efficient procedure for the selective preparation of hydroxy-, carbonyl- and acetal-containing 2-pyrrolidinones has been developed through radical cyclization of 1,6-dienes initiated by alpha-C(sp(3))-H functionalization of alcohols. This protocol could be conducted at catalyst-free conditions at relatively low temperature (80 degrees C) by employing commercially available tert-butyl peroxybenzoate (TBPB) as the oxidant. (C) 2020 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
